Ann Dermatol Venereol. 2005 Dec;132(12 Pt 1):986-9.
Primary cutaneous extraskeletal Ewing's sarcoma
[Article in French]
Kourda M, Chatti S, Sfia M, Kraiem W, Ben Brahim E.
Service de Dermatologie, Hopital de Nabeul, Tunisie.
kourda_mouna@yahoo.fr
BACKGROUND: Cutaneous extraskeletal Ewing's sarcoma is rare, being seen
principally in children. We report a case of cutaneous sarcoma in the
sole of the foot in a child. CASE REPORT: A 9-year-old child with no
medical history of note was presenting a skin tumor for 3 months on the
heel of the right foot. This tumor was burgeoning and painful and
measured 3.5 cm in diameter; it was ulcerative at the surface and
covered with a crust. Histological and immunohistochemical examinations
confirmed the diagnosis of Ewing's sarcoma. Staging examinations proved
negative and the patient underwent polychemotherapy, resulting in
complete regression of the tumor. COMMENTS: Until 1998, 37 cases of
cutaneous and subcutaneous Ewing's sarcoma were reported, being seen in
21 girls and 16 boys. Mean age at diagnosis was 15 years and mean tumor
size was 3 cm (range: 1 to 12 cm). The tumors were observed throughout
the body, being seen in the sole of the foot in 2 cases. Confirmation
of the diagnosis was made by histological examination (malignant
proliferation of small round cells in the dermis), immunohistochemical
examination (CD99+) and cytogenetic analysis (translocation between
chromosomes 22 and 11). The prognosis for cutaneous Ewing's sarcoma
appears more favorable than that of Ewing's sarcoma in bone. Of the 37
patients treated, 7 had metastases and 2 presented relapse. Treatment
for cutaneous Ewing's sarcoma, though not codified, consists of
polychemotherapy associated with surgery and/or radiotherapy.
PMID: 16446642 [PubMed – in process]