Pediatr Blood Cancer. 2006 Jan 12; [Epub ahead of print]
Second and third malignant solid tumor in a girl
with ovarian Sertoli-Leydig tumor.
Panagiotou JP, Polychronopoulou S, Sofou K, Vanvliet-Constantinidou C,
Papandreou E, Haidas S.
Department of Pediatric Hematology/Oncology, “Aghia Sophia” Children's
Hospital, Athens, Greece.
We report a Sertoli-Leydig cell (SLC) tumor of the right ovary in a
10-year-old girl, which was dealt with surgical removal. Three months
after resection, she presented with a new episode of acute abdomen
because of an abdominal mass, which histologically was compatible with
an undifferentiated embryonal rhabdomyosarcoma. Chemotherapy, according
to SIOP-??? 89 protocol, was administered additionally to radiotherapy
(3,960 cGy). Three years after completing treatment, the patient
developed a painful swelling at her left upper arm. The diagnosis was
Ewing sarcoma of the humerus, which was confirmed by identification of
the typical 11; 22 translocation on cytogenetic and molecular analysis
of the tumor tissue. The patient died 14 months from Ewing diagnosis
due to progressive disease. Pediatr Blood Cancer (c) 2006 Wiley-Liss,
Inc.
PMID: 16411221 [PubMed – as supplied by publisher]